Our Work
學術發表

Selected Publications

代表性論文

Peer-reviewed research contributions from TMS Laboratory members.

TMS 實驗室成員的同行評審研究成果。

2022 – Present
2022 – 現在
2025

CD24a knockout results in an enhanced macrophage- and CD8+ T cell-mediated anti-tumor immune responses in tumor microenvironment in a murine triple-negative breast cancer model

Chan SH, Lin CY, Tseng HJ, Wang LH
Journal of Biomedical Science · 32(1):73 · PMID: 40783744
CD24 TNBC Immunotherapy 免疫治療
2025

ST6GAL1-Mediated Sialylation of PECAM-1 Promotes a Transcellular Diapedesis-Like Process That Directs Lung Tropism of Metastatic Breast Cancer

Chen SY, He PL, Lu LY, Lin MC, Chan SH, Tsai JS, Luo WT, Wang LH, Li HJ
Cancer Research · 85(7):1199–1218 · PMID: 39786386
Breast Cancer Metastasis 乳癌轉移 Sialylation
2023

SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer

Chan SH, Kuo WH, Wang LH
Journal of Biomedical Science · 30(1):93 · PMID: 38037106
TNBC Lung Metastasis 肺轉移 NF-κB
2023

Dual antibody-aided mesoporous nanoreactor for H₂O₂ self-supplying chemodynamic therapy and checkpoint blockade immunotherapy in triple-negative breast cancer

Chen YT, Luo YX, Chan SH, Chiu WY, Yang HW
Journal of Nanobiotechnology · 21(1):385 · PMID: 37875918
Nanomedicine 奈米醫學 TNBC PD-L1 CD24
2023

MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression

Kuo WH, Chu PY, Wang CC, Huang PS, Chan SH
Biology Direct · 18(1):44 · PMID: 37550720
TNBC MAP7D3 Cancer Stemness 癌幹細胞
Before 2022
2022 年以前
2021

LOC550643, a Long Non-coding RNA, Acts as Novel Oncogene in Regulating Breast Cancer Growth and Metastasis

Tsai KW, Chong KH, Li CH, Tu YT, Chen YR, Lee MC, Chan SH, Wang LH, Chang YJ
Frontiers in Cell and Developmental Biology · 9:695632 · PMID: 34354991
lncRNA Breast Cancer 乳癌
2021

Cure the Incurable? Recent Breakthroughs in Immune Checkpoint Blockade for Hepatocellular Carcinoma

Chu PY, Chan SH
Cancers (Basel) · 13(21):5295 · PMID: 34771459
HCC Immune Checkpoint 免疫檢查點 Review 綜述
2020

Identification of the Novel Oncogenic Role of SAAL1 and Its Therapeutic Potential in Hepatocellular Carcinoma

Chu PY, Tung SL, Tsai KW, Shen FP, Chan SH
Cancers (Basel) · 12(7):1843 · PMID: 32650537
HCC SAAL1 Oncogene 癌基因
2019

Identification of the Novel Role of CD24 as an Oncogenesis Regulator and Therapeutic Target for Triple-Negative Breast Cancer

Chan SH, Tsai KW, Chiu SY, Kuo WH, Chen HY, Jiang SS, Chang KJ, Hung WC, Wang LH
Molecular Cancer Therapeutics · 18(1):147–161 · PMID: 30381446
CD24 TNBC First Author 第一作者
2019

Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis

Wang YH, Huang JT, Chen WL, Wang RH, Kao MC, Pan YR, Chan SH, Tsai KW, Kung HJ, Lin KT, Wang LH
EMBO Reports · 20(10):e45986 · PMID: 31468690
Prostate Cancer 攝護腺癌 Metastasis 轉移
2019

Cancer-Derived VEGF-C Increases Chemokine Production in Lymphatic Endothelial Cells to Promote CXCR2-Dependent Cancer Invasion and MDSC Recruitment

Chen JY, Lai YS, Chu PY, Chan SH, Wang LH, Hung WC
Cancers (Basel) · 11(8):1120 · PMID: 31390756
VEGF-C MDSC Invasion 侵襲
2019

A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway

Huang WC, Jang TH, Tung SL, Yen TC, Chan SH, Wang LH
Journal of Experimental & Clinical Cancer Research · 38(1):89 · PMID: 30782177
miRNA Oral Cancer 口腔癌
2018

Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the α-Ketoglutarate Signaling Pathway

Tseng CW, Kuo WH, Chan SH, Chan HL, Chang KJ, Wang LH
Cancer Research · 78(11):2799–2812 · PMID: 29599405
Breast Cancer 乳癌 Metabolism 代謝
2018

Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7-CYFIP1-mediated signaling pathway

Chang JW, Kuo WH, Lin CM, Chen WL, Chan SH, et al.
Oncogene · 37(30):4137–4150 · PMID: 29706651
p53 Breast Cancer 乳癌 Metastasis Suppression 轉移抑制
2018

Isocitrate dehydrogenase 1-snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability

Liu WS, Chan SH, Chang HT, Li GC, Tu YT, Tseng HH, Fu TY, Chang HY, Liou HH, Ger LP, Tsai KW
Breast Cancer Research · 20(1):25 · PMID: 29661250
IDH1 Snail Breast Cancer 乳癌
2017

SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease

Chan SH, Hung CH, Shih JY, Chu PM, Cheng YH, Lin HC, Tsai KL
Redox Biology · 13:301–309 · PMID: 28601780
SIRT1 First Author 第一作者 Coronary Artery Disease 冠狀動脈疾病
2017

The expression of a tumor suppressor gene JDP2 and its prognostic value in hepatocellular carcinoma patients

Chen YL, Chan SH, Lin PY, Chu PY
Human Pathology · 63:212–216 · PMID: 28315425
JDP2 HCC Tumor Suppressor 抑癌基因
2015

Regulation of cancer metastasis by microRNAs

Chan SH, Wang LH
Journal of Biomedical Science · 22(1):9 · PMID: 25614041
miRNA First Author 第一作者 Review 綜述
2014

MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis

Chan SH, Huang WC, Chang JW, Chang KJ, Kuo WH, Wang MY, Lin KY, Uen YH, Hou MF, Lin CM, Jang TH, Tu CW, Lee YR, Lee YH, Tien MT, Wang LH
Oncogene · 33:4496–4507 · 2014
miRNA GIT1 First Author 第一作者 Breast Cancer 乳癌